Glutathione peroxidase 8

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.^[5][6] GPx-8 is a member of the glutathione peroxidase family.

GPX8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CYN, 3KIJ
Identifiers
Aliases	GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)
External IDs	OMIM: 617172; MGI: 1916840; HomoloGene: 88454; GeneCards: GPX8; OMA:GPX8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.2 Start 55,160,167 bp[1] End 55,167,297 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D2.2 Start 113,179,287 bp[2] End 113,182,944 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium tibia germinal epithelium placenta smooth muscle tissue Achilles tendon parietal pleura gonad synovial membrane corpus epididymis Top expressed in calvaria umbilical cord efferent ductule Epithelium of choroid plexus vestibular sensory epithelium decidua interventricular septum uterus intercostal muscle cervix More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity glutathione peroxidase activity peroxidase activity Cellular component integral component of membrane endoplasmic reticulum lumen membrane Biological process response to oxidative stress cellular oxidant detoxification cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 493869 69590 Ensembl ENSG00000164294 ENSMUSG00000021760 UniProt Q8TED1 Q9D7B7 RefSeq (mRNA) NM_001008397 NM_001306197 NM_001306198 NM_001306201 NM_027127 RefSeq (protein) NP_001008398 NP_001293126 NP_001293127 NP_001293130 NP_081403 Location (UCSC) Chr 5: 55.16 – 55.17 Mb Chr 13: 113.18 – 113.18 Mb PubMed search [3] [4]
Wikidata
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