Gadoxetic acid

Gadoxetic acid is a gadolinium-based MRI contrast agent.^[4] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.^[2][5]

Gadoxetic acid

Clinical data
Trade names	Eovist
Other names	Gadoxetate disodium (USAN US)
AHFS/Drugs.com	International Drug Names
ATC code	V08CA10 (WHO)
Legal status
Legal status	CA: ℞-only[1] US: ℞-only[2] EU: Rx-only[3]
Identifiers
IUPAC name 2-[[2-[bis(2-oxido-2-oxoethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium(+3) cation
CAS Number	135326-11-3 Y
PubChem CID	131704314
DrugBank	DB08884 Y
ChemSpider	189907
UNII	3QJA87N40S
KEGG	D08008 Y D04288
ChEMBL	ChEMBL1201768 N
CompTox Dashboard (EPA)	DTXSID90928961
Chemical and physical data
Formula	C23H30GdN3O11
Molar mass	681.75 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOc1ccc(cc1)C[C@@H](CN(CCN(CC(=O)O)CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Gd+3]
InChI InChI=1S/C23H33N3O11.Gd/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);/q;+3/p-3/t17-;/m0./s1 Key:PCZHWPSNPWAQNF-LMOVPXPDSA-K
NY (what is this?)  (verify)

Medical uses

It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, hemangioma, and liver cancer. It is excreted into bile by active secretion.^[6]

Pharmacokinetics

In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than those with normal renal function.^[6]