LGALS13

Placental protein 13 (PP13, also known as galectin-13) is a protein that in humans is encoded by the LGALS13 gene.^[3][4]

LGALS13
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1F87
Identifiers
Aliases	LGALS13, GAL13, PLAC8, PP13, galectin 13
External IDs	OMIM: 608717; HomoloGene: 49329; GeneCards: LGALS13; OMA:LGALS13 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,602,524 bp[1] End 39,607,474 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta thymus striated muscle tissue skeletal muscle tissue thigh muscle of thigh cerebellum cerebellar cortex right hemisphere of cerebellum hypothalamus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lysophospholipase activity protein binding carbohydrate binding Cellular component cytoplasm nuclear matrix nucleus Biological process phospholipid metabolic process positive regulation of T cell apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29124 n/a Ensembl ENSG00000105198 n/a UniProt Q9UHV8 n/a RefSeq (mRNA) NM_013268 n/a RefSeq (protein) NP_037400 n/a Location (UCSC) Chr 19: 39.6 – 39.61 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Structure and function

It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galactoside. This is because the ligand binding site is lack of key residue for binding beta-galactoside. ^[5]It is a galectin-like protein.

Galectin-13 has been shown to bind CD44, inhibiting membrane localization of SLC7A11 and promoting propagation of ferroptosis.^[6]

Clinical significance

PP13 levels that are low in the first trimester of pregnancy confers a higher risk for developing pre-eclampsia later in pregnancy.^[7]