Gedunin

Gedunin is a pentacyclic triterpenoid with the molecular formula C₂₈H₃₄ O₇. It is most notably found in Azadirachta indica,^[1] but is a constituent of several other plants. Gedunin shows therapeutic potential in the treatment of leukemia,^[2] and Parkinson's disease.^[3][4]

Gedunin

Names
IUPAC name Gedunin
Systematic IUPAC name [(1S,2R,4S,7S,8S,11R,12R,17R,19R)-7-(furan-3-yl)-1,8,12,16,16-pentamethyl-5,15-dioxo-3,6-dioxapentacyclo[9.8.0.02,4.02,8.012,17]nonadec-13-en-19-yl] acetate
Other names Gedunine (-)-Gedunin (1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-1-(Furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Natural occurrence

Azadirachta indica^[5] is the most notable source of gedunin, but it has also been found in the following plants:

• Cedrela fissilis^[6]
• Cedrela odorata^[7][8]
• Cedrela salvadorensis^[9]
• Entandrophragma angolense^[10]
• Khaya grandifoliola^[11]
• Melia azedarach^[12]
• Toona sinensis^[13][14]
• Xylocarpus granatum^[15][16]