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Geroprotector

Medical therapy against aging From Wikipedia, the free encyclopedia

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A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.[1][2] Some possible geroprotectors include melatonin,[3] carnosine,[4] metformin,[5] rapamycin,[6] nicotinamide mononucleotide (NMN),[7] delta sleep-inducing peptide[8] and glycine.[9]

Geroprotectors could belong to multiple classes, depending on which of the hallmarks of aging they influence.[10][11]

The distinction between geroprotectors and senotherapeutics is an evolving area of aging research. Geroprotectors broadly aim to target multiple mechanisms of aging, prolonging lifespan and healthspan by addressing the fundamental causes of aging. Senotherapeutics, on the other hand, are a subset of therapies that specifically target senescent cells, which are dysfunctional cells that accumulate with age and contribute to inflammation and age-related diseases.[12]

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