GRIA1

Glutamate receptor 1 is a protein that in humans is encoded by the GRIA1 gene.^[5][6]

GRIA1
Identifiers
Aliases	GRIA1, GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate ionotropic receptor AMPA type subunit 1, Glutamate receptor, ionotropic, AMPA 1
External IDs	OMIM: 138248; MGI: 95808; HomoloGene: 20226; GeneCards: GRIA1; OMA:GRIA1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 153,489,615 bp[1] End 153,813,869 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 34.51 cM Start 56,902,213 bp[2] End 57,221,070 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Region I of hippocampus proper optic nerve middle temporal gyrus ganglionic eminence paraflocculus of cerebellum ventricular zone right hemisphere of cerebellum entorhinal cortex prefrontal cortex Brodmann area 46 Top expressed in lateral septal nucleus subiculum dentate gyrus ventromedial nucleus Region I of hippocampus proper anterior amygdaloid area dentate gyrus of hippocampal formation granule cell hippocampus proper CA3 field entorhinal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function glutamate receptor activity PDZ domain binding AMPA glutamate receptor activity ion channel activity protein binding ionotropic glutamate receptor activity extracellularly glutamate-gated ion channel activity excitatory extracellular ligand-gated ion channel activity neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential amyloid-beta binding signaling receptor activity Cellular component integral component of membrane recycling endosome endocytic vesicle membrane postsynaptic membrane cell projection endoplasmic reticulum membrane membrane synaptic vesicle postsynaptic density axonal spine plasma membrane dendritic spine synapse dendrite membrane cell surface cell junction soma dendrite endoplasmic reticulum dendritic spine membrane neuron spine ER to Golgi transport vesicle membrane neuron projection AMPA glutamate receptor complex ionotropic glutamate receptor complex endoplasmic reticulum-Golgi intermediate compartment membrane Golgi membrane postsynapse postsynaptic density membrane endosome early endosome membrane somatodendritic compartment recycling endosome membrane synaptic membrane glutamatergic synapse integral component of postsynaptic density membrane Biological process receptor internalization ion transport endoplasmic reticulum to Golgi vesicle-mediated transport ion transmembrane transport COPII vesicle coating long-term memory transport long-term depression signal transduction chemical synaptic transmission ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential regulation of postsynaptic membrane potential regulation of postsynaptic cytosolic calcium ion concentration chemical synaptic transmission, postsynaptic regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2890 14799 Ensembl ENSG00000155511 ENSMUSG00000020524 UniProt P42261 P23818 RefSeq (mRNA) NM_000827 NM_001114183 NM_001258019 NM_001258020 NM_001258021 NM_001258022 NM_001258023 NM_001364165 NM_001364166 NM_001364167 NM_001113325 NM_001252403 NM_008165 RefSeq (protein) NP_000818 NP_001107655 NP_001244948 NP_001244949 NP_001244950 NP_001244951 NP_001244952 NP_001351094 NP_001351095 NP_001351096 NP_001106796 NP_001239332 NP_032191 Location (UCSC) Chr 5: 153.49 – 153.81 Mb Chr 11: 56.9 – 57.22 Mb PubMed search [3] [4]
Wikidata
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Function

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1–4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.^[7]

GRIA1 (GluR1) is centrally involved in synaptic plasticity. Expression of the GluR1 gene is significantly reduced in the human frontal cortex with increasing age.^[8]

Interactions

GRIA1 has been shown to interact with:

• DLG1^[9][10][11]
• EPB41L2,^[12] and
• GRID2.^[13]

See also

• AMPA receptor