Gluconate 5-dehydrogenase

In enzymology, gluconate 5-dehydrogenase (EC 1.1.1.69) is an enzyme that catalyzes the chemical reaction

D-gluconic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

5-oxo-D-gluconic acid

+ NADH

 

gluconate 5-dehydrogenase
Identifiers
EC no.	1.1.1.69
CAS no.	9028-70-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are D-gluconic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 5-oxo-D-gluconic acid, reduced NADH, and a proton. The enzyme can use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.^[1][2][3][4]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-gluconate:NAD(P)⁺ 5-oxidoreductase. Other names in common use include 5-keto-D-gluconate 5-reductase, 5-keto-D-gluconate 5-reductase, 5-ketogluconate 5-reductase, 5-ketogluconate reductase, and 5-keto-D-gluconate reductase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1VL8.