GLYCAM1

Glycosylation-dependent cell adhesion molecule-1 is a protein that is encoded by the GLYCAM1 gene. In humans, GLYCAM1 is a pseudogene while in many other mammals including mouse, it is a protein coding gene.

GLYCAM1
Identifiers
Aliases	GLYCAM1, glycosylation dependent cell adhesion molecule 1 (pseudogene)
External IDs	MGI: 95759; GeneCards: GLYCAM1; OMA:GLYCAM1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 54,608,187 bp[1] End 54,610,462 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 59.03 cM Start 103,471,186 bp[2] End 103,473,508 bp[2]
Orthologs Species Human Mouse Entrez 644076 14663 Ensembl ENSG00000257780 ENSMUSG00000022491 UniProt n a Q02596 RefSeq (mRNA) n/a NM_001289587 NM_008134 RefSeq (protein) n/a NP_001276516 NP_032160 Location (UCSC) Chr 12: 54.61 – 54.61 Mb Chr 15: 103.47 – 103.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.^[5][6] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.^{[citation needed]} Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.^[7]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.^[5]