Glycerol-3-phosphate 1-dehydrogenase (NADP+)

In enzymology, glycerol-3-phosphate 1-dehydrogenase (NADP⁺) (EC 1.1.1.177) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate

+ NADP⁺

 

 

 

H⁺

 

H⁺

 

D-glyceraldehyde 3-phosphate

+ NADPH

 

glycerol-3-phosphate 1-dehydrogenase (NADP+)
Identifiers
EC no.	1.1.1.177
CAS no.	37213-46-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are D-glyceraldehyde 3-phosphate, reduced NADPH, and a proton.^[1][2][3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NADP⁺ 1-oxidoreductase. Other names in common use include glycerol phosphate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, L-glycerol 3-phosphate:NADP⁺ oxidoreductase, glycerin-3-phosphate dehydrogenase, NADPH-dependent glycerin-3-phosphate dehydrogenase, and glycerol-3-phosphate 1-dehydrogenase (NADP⁺).