Glycerol-3-phosphate dehydrogenase (NAD(P)+)

In enzymology, a glycerol-3-phosphate dehydrogenase [NAD(P)⁺] (EC 1.1.1.94) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NAD(P)⁺ ${\displaystyle \rightleftharpoons }$ glycerone phosphate + NAD(P)H + H⁺

glycerol-3-phosphate dehydrogenase [NAD(P)+]
Identifiers
EC no.	1.1.1.94
CAS no.	37250-30-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are sn-glycerol 3-phosphate, NAD⁺, and NADP⁺, whereas its 4 products are glycerone phosphate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include L-glycerol-3-phosphate:NAD(P)⁺ oxidoreductase, glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide, (phosphate)), glycerol 3-phosphate dehydrogenase (NADP⁺), and glycerol-3-phosphate dehydrogenase [NAD(P)⁺]. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TXG.