TMBIM4

Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene.^[5][6][7] It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.

TMBIM4
Identifiers
Aliases	TMBIM4, GAAP, LFG4, S1R, ZPRO, CGI-119, transmembrane BAX inhibitor motif containing 4
External IDs	OMIM: 616874; MGI: 1915462; HomoloGene: 56740; GeneCards: TMBIM4; OMA:TMBIM4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.3 Start 66,135,846 bp[1] End 66,170,027 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 120,037,495 bp[2] End 120,060,822 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell monocyte Achilles tendon body of pancreas right lung left adrenal gland left testis right testis right adrenal gland right adrenal cortex Top expressed in right kidney interventricular septum yolk sac human kidney seminal vesicula proximal tubule granulocyte neural layer of retina spermatocyte spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane Golgi apparatus Golgi membrane Golgi stack membrane Biological process regulation of calcium-mediated signaling negative regulation of apoptotic process apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51643 68212 Ensembl ENSG00000155957 ENSMUSG00000020225 UniProt Q9HC24 Q9DA39 RefSeq (mRNA) NM_016056 NM_001282606 NM_001282609 NM_001282610 NM_026617 RefSeq (protein) NP_001269535 NP_001269538 NP_001269539 NP_057140 NP_001269535.1 NP_080893 Location (UCSC) Chr 12: 66.14 – 66.17 Mb Chr 10: 120.04 – 120.06 Mb PubMed search [3] [4]
Wikidata
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Function

Human GAAP ^[8] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca⁺², an increase of GAAP can help prevent apoptosis.^[9][10] GAAP is also involved in promoting cell migration^{[11] [12]} and has been identified as a novel Golgi cation channel.^[13] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.

See also

• Golgi
• Apoptosis
• Ion channel
• Cell migration