Gq-mER

The G_q-coupled membrane estrogen receptor (G_q-mER) is a G protein-coupled receptor present in the hypothalamus that has not yet been cloned.^[1][2] It is a membrane-associated receptor that is G_q-coupled to a phospholipase C–protein kinase C–protein kinase A (PLC–PKC–PKA) pathway.^[1][2] The receptor has been implicated in the control of energy homeostasis.^[1] G_q-mER is bound and activated by estradiol, and is a putative membrane estrogen receptor (mER).^[1][2] A nonsteroidal diphenylacrylamide derivative, STX, which is structurally related to 4-hydroxytamoxifen (afimoxifene), is an agonist of the receptor with greater potency than estradiol (20-fold higher affinity) that has been discovered.^[1][2][3] Fulvestrant (ICI-182,780) has been identified as an antagonist of G_q-mER, but is not selective.^[3]

See also

• Estrogen receptor
• GPER (GPR30)
• ER-X
• ERx