ARHGAP26

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a protein that in humans is encoded by the ARHGAP26 gene.^[5][6][7]

ARHGAP26
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGV
Identifiers
Aliases	ARHGAP26, GRAF, GRAF1, OPHN1L, OPHN1L1, Rho GTPase activating protein 26
External IDs	OMIM: 605370; MGI: 1918552; HomoloGene: 36349; GeneCards: ARHGAP26; OMA:ARHGAP26 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 142,770,377 bp[1] End 143,229,011 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 39,126,198 bp[2] End 39,509,337 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve blood epithelium of colon monocyte right uterine tube testicle granulocyte bone marrow cells Achilles tendon postcentral gyrus Top expressed in interventricular septum lobe of cerebellum cerebellar vermis zygote otolith organ utricle prefrontal cortex subiculum anterior amygdaloid area visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipid binding GTPase activator activity Cellular component cytoplasm cytosol cell junction cytoskeleton focal adhesion cellular component Biological process regulation of small GTPase mediated signal transduction actin cytoskeleton organization nervous system development signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23092 71302 Ensembl ENSG00000145819 ENSMUSG00000036452 UniProt Q9UNA1 Q6ZQ82 RefSeq (mRNA) NM_001135608 NM_015071 NM_001349547 NM_175164 NM_001361073 NM_001374831 RefSeq (protein) NP_001129080 NP_055886 NP_001336476 NP_780373 NP_001348002 NP_001361760 Location (UCSC) Chr 5: 142.77 – 143.23 Mb Chr 18: 39.13 – 39.51 Mb PubMed search [3] [4]
Wikidata
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Function

GRAF1 is a multidomain protein that is necessary for the CLIC/GEEC endocytic pathway.^[8] By virtue of an N-terminal BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of dynamin action abrogates CLIC/GEEC endocytosis. There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (leukaemia and mental retardation, respectively). Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune cerebellar ataxia.^[9][10][11]

Interactions

ARHGAP26 has been shown to interact with PKN3.^[12]