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Guadinomine

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Guadinomine
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Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509.[1] Guadinomine B is the most potent known inhibitor of the Type III secretion system (TTSS) of Gram-negative bacteria. The guadinomine (gdn) biosynthetic gene cluster includes 26 open reading frames spanning 51.2 kb. Streptomyces sp. K01-0509 produces several derivatives named guadinomines A, B, C1, C2, D, and guadinomic acid.[2]

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Chemical structure of guadinomine B
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