HIST1H1D

Histone H1.3 is a protein encoded by the HIST1H1D gene in humans.^[5][6][7]

H1-3
Identifiers
Aliases	H1-3, H1.3, H1D, H1F3, H1s-2, histone cluster 1, H1d, histone cluster 1 H1 family member d, H1.3 linker histone, cluster member, HIST1H1D
External IDs	OMIM: 142210; MGI: 107502; HomoloGene: 68456; GeneCards: H1-3; OMA:H1-3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,234,212 bp[1] End 26,234,987 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,737,436 bp[2] End 23,744,860 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gonad epithelium of colon bone marrow cell testicle ventricular zone tonsil embryo sural nerve ganglionic eminence Top expressed in gray matter layer of cerebellum seminiferous tubule hair follicle mandibular prominence primitive streak abdominal wall ascending aorta aortic valve fossa endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin DNA binding RNA binding double-stranded DNA binding protein binding nucleosomal DNA binding Cellular component nucleosome nucleus chromosome Biological process regulation of transcription by RNA polymerase II histone H3-K4 trimethylation nucleosome assembly negative regulation of transcription by RNA polymerase II histone H3-K27 trimethylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3007 14957 Ensembl ENSG00000124575 ENSMUSG00000052565 UniProt P16402 P43277 RefSeq (mRNA) NM_005320 NM_145713 RefSeq (protein) NP_005311 NP_663759 Location (UCSC) Chr 6: 26.23 – 26.23 Mb Chr 13: 23.74 – 23.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that play a crucial role in the nucleosome structure of chromosomal fibers in eukaryotes. Two molecules each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped to create repeating units called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and facilitates the compaction of chromatin into higher-order structures. This intronless gene encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails and instead contain a palindromic termination element. This gene is located within the large histone gene cluster on chromosome 6.^[7]