H1299

H1299, also known as NCI-H1299^[1][2] or CRL-5803,^[3] is a human non-small cell lung carcinoma cell line derived from the lymph node, which is widely used in research.^[4]

As with other immortalized cell lines, H1299 cells can divide indefinitely. These cells have a homozygous partial deletion of the TP53 gene and as a result, do not express the tumor suppressor p53 protein which in part accounts for their proliferative propensity.^[5] These cells have also been reported to secrete the peptide hormone neuromedin B (NMB), but not gastrin releasing peptide (GRP).^[4]