H2AFB2

Histone H2A-Bbd type 2/3 also known as H2A Barr body-deficient is a histone protein that in humans is encoded by the H2AFB2 gene (H2A histone family, member B1).^[5]

H2AB2
Identifiers
Aliases	H2AB2, H2A.Bbd, H2A histone family member B2, H2A.B variant histone 2, H2AFB2, H2AB3, H2A.B.1
External IDs	MGI: 3644875; HomoloGene: 129517; GeneCards: H2AB2; OMA:H2AB2 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,380,709 bp[1] End 155,381,299 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E2 Start 119,222,445 bp[2] End 119,222,792 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left testis granulocyte right testis mucosa of transverse colon right uterine tube gastric mucosa primary visual cortex canal of the cervix right adrenal cortex Top expressed in testicle spermatid striatum of neuraxis Cortex of frontal lobe Cerebellum Hypothalamus Mesencephalon superior frontal gyrus primary visual cortex spleen More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome Biological process nucleosome assembly mRNA processing chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 474381 624957 Ensembl ENSG00000277858 ENSMUSG00000083616 UniProt P0C5Z0 S4R1G7 RefSeq (mRNA) NM_001017991 NM_001281531 RefSeq (protein) NP_001017991 NP_001268460 Location (UCSC) Chr X: 155.38 – 155.38 Mb Chr X: 119.22 – 119.22 Mb PubMed search [3] [4]
Wikidata
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Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the middle copy.^[5]