H2AFB3

H2A histone family, member B3 is a protein that in humans is encoded by the H2AFB3 gene.^[5]

H2AB3
Identifiers
Aliases	H2AB3, H2ABBD, H2AFB, H2A histone family member B3, H2A.B variant histone 3, H2AFB3, H2AB2, H2A.B.1
External IDs	OMIM: 300445; MGI: 3644980; HomoloGene: 129517; GeneCards: H2AB3; OMA:H2AB3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 155,459,415 bp[1] End 155,460,005 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X E1 Start 115,590,875 bp[2] End 115,591,222 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right coronary artery right testis right ovary left uterine tube spleen blood gastric mucosa canal of the cervix duodenum Top expressed in spleen thymus dentate gyrus of hippocampal formation granule cell lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome Biological process nucleosome assembly mRNA processing chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83740 624153 Ensembl ENSG00000277745 ENSMUSG00000082482 UniProt P0C5Z0 S4R1M3 RefSeq (mRNA) NM_080720 NM_001281530 RefSeq (protein) NP_001017991 NP_001268459 Location (UCSC) Chr X: 155.46 – 155.46 Mb Chr X: 115.59 – 115.59 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most telomeric copy. [provided by RefSeq, Jul 2008].^[5]