HIST2H2AA3

Histone H2A type 2-A is a protein that in humans is encoded by the HIST2H2AA3 gene.^[5][6][7][8]

H2AC18
Identifiers
Aliases	H2AC18, H2A, H2A.2, H2A/O, H2A/q, H2AFO, H2a-615, HIST2H2AA, histone cluster 2, H2aa3, histone cluster 2 H2A family member a3, HIST2H2AA3, H2A clustered histone 18, H2AC19
External IDs	OMIM: 142720; MGI: 2448283; HomoloGene: 116071; GeneCards: H2AC18; OMA:H2AC18 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,842,218 bp[1] End 149,842,750 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,147,065 bp[2] End 96,147,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stomach blood colon Achilles tendon testicle corpus callosum right lung prostate Top expressed in white adipose tissue uterus granulocyte adrenal gland spermatocyte proximal tubule pancreas urinary bladder islet of Langerhans muscle of thigh More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component nucleosome extracellular exosome nucleus chromosome Biological process chromatin organization biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8337 319192 Ensembl ENSG00000288825 ENSMUSG00000063954 UniProt Q6FI13 Q6GSS7 RefSeq (mRNA) NM_003516 NM_178212 RefSeq (protein) NP_001035807 NP_003507 NP_038577 NP_835584 Location (UCSC) Chr 1: 149.84 – 149.84 Mb Chr 3: 96.15 – 96.15 Mb PubMed search [3] [4]
Wikidata
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Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.^[8]