HIST1H2AC

Histone H2A type 1-C is a protein that in humans is encoded by the HIST1H2AC gene.^[5][6][7]

H2AC6
Identifiers
Aliases	H2AC6, H2A/l, H2AFL, dJ221C16.4, histone cluster 1, H2ac, histone cluster 1 H2A family member c, HIST1H2AC, H2A clustered histone 6
External IDs	OMIM: 602794; MGI: 2448302; HomoloGene: 130459; GeneCards: H2AC6; OMA:H2AC6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,124,145 bp[1] End 26,139,116 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,994,635 bp[2] End 21,995,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood buccal mucosa cell pericardium jejunal mucosa mucosa of transverse colon optic nerve granulocyte bone marrow C1 segment Top expressed in embryo embryo neural tube blastocyst urinary bladder morula tail of embryo granulocyte bone marrow mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding molecular function Cellular component nucleosome nucleus chromosome extracellular exosome nucleoplasm Biological process negative regulation of cell population proliferation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8334 665433 Ensembl ENSG00000180573 ENSMUSG00000094248 UniProt Q93077 C0HKE2 B2RVF0 C0HKE1 C0HKE3 C0HKE4 C0HKE5 C0HKE6 C0HKE7 C0HKE8 C0HKE9 RefSeq (mRNA) NM_003512 NM_001177544 RefSeq (protein) NP_003503 NP_835496 NP_835495 NP_835494 NP_835491 NP_835489 NP_783591 NP_835493 NP_835496 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835489 NP_001171015 NP_835496 NP_835491 NP_835493 NP_835494 NP_835495 NP_835492 NP_783591 NP_835494 NP_835489 NP_835495 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835495 NP_835489 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835492 NP_835491 NP_835489 NP_835495 NP_835494 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835491 NP_835489 NP_835495 NP_835494 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 Location (UCSC) Chr 6: 26.12 – 26.14 Mb Chr 13: 21.99 – 22 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[7]

Cancer

HIST1H2AC gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[8] For this reason, HIST1H2AC is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[8]