HIST2H2BE

Histone H2B type 2-E is a protein that in humans is encoded by the HIST2H2BE gene.^[5][6][7]

H2BC21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NFT
Identifiers
Aliases	H2BC21, GL105, H2B, H2B.1, H2BFQ, H2BGL105, H2BQ, histone cluster 2, H2be, histone cluster 2 H2B family member e, H2B clustered histone 21, HIST2H2BE, H2BE, H2B-GL105
External IDs	OMIM: 601831; MGI: 2448409; HomoloGene: 128426; GeneCards: H2BC21; OMA:H2BC21 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 149,884,459 bp[1] End 149,886,682 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,971,631 bp[2] End 21,973,383 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle monocyte left ventricle right uterine tube prostate ganglionic eminence apex of heart myocardium of left ventricle gastrocnemius muscle tibialis anterior muscle Top expressed in spermatid uterus spermatocyte testicle genital tubercle embryo ileum bone marrow embryo quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component chromosome extracellular exosome nucleoplasm nucleosome nucleus extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8349 319188 Ensembl ENSG00000184678 ENSMUSG00000069308 UniProt Q16778 Q8CGP2 RefSeq (mRNA) NM_003528 NM_001290466 NM_178202 RefSeq (protein) NP_003519 NP_001277395 NP_835509 Location (UCSC) Chr 1: 149.88 – 149.89 Mb Chr 13: 21.97 – 21.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.^[7]

Cancer

HIST2H2BE gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[8] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[8]