HIST1H2BD

Histone H2B type 1-D is a protein that in humans is encoded by the HIST1H2BD gene.^[5][6][7]

H2BC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC5, H2B.1B, H2B/b, H2BFB, HIRIP2, dJ221C16.6, histone cluster 1, H2bd, histone cluster 1 H2B family member d, H2BFG, H2BFL, H2B/k, H2B/l, H2B/h, H2BFK, HIST1H2BE, HIST1H2BC, HIST1H2BG, HIST1H2BI, H2BFA, H2BFH, H2B/a, H2B/g, HIST1H2BF, HIST1H2BD, H2B clustered histone 5
External IDs	OMIM: 602799; MGI: 1925553; HomoloGene: 134740; GeneCards: H2BC5; OMA:H2BC5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,158,122 bp[1] End 26,171,349 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,839,746 bp[2] End 58,840,359 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube Achilles tendon mucosa of transverse colon pylorus prostate epithelium of colon tendon of biceps brachii right lobe of liver right ventricle ganglionic eminence Top expressed in medial ganglionic eminence ventricular zone lens spermatid cerebellar cortex trigeminal ganglion spermatocyte embryo neural layer of retina visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding molecular function protein binding identical protein binding Cellular component chromosome nucleosome extracellular exosome nucleoplasm nucleus cytosol extracellular space Biological process nucleosome assembly protein ubiquitination innate immune response in mucosa defense response to bacterium antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3017 78303 Ensembl ENSG00000158373 ENSMUSG00000056895 UniProt P58876 P62807 Q9D2U9 RefSeq (mRNA) NM_021063 NM_138720 NM_030082 RefSeq (protein) NP_066407 NP_619790 NP_003517 NP_001368918 NP_084358 Location (UCSC) Chr 6: 26.16 – 26.17 Mb Chr 11: 58.84 – 58.84 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryote. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.^[7]