HIST1H2BF

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BF gene.^[5][6][7]

H2BC7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC7, H2B/g, H2BFG, histone cluster 1, H2bf, histone cluster 1 H2B family member f, H2B clustered histone 7, HIST1H2BF, H2BC10, H2BC8, H2BC6, H2BC4
External IDs	OMIM: 602804; MGI: 2448380; HomoloGene: 136358; GeneCards: H2BC7; OMA:H2BC7 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,199,516 bp[1] End 26,199,988 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,767,653 bp[2] End 23,805,107 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad tendon of biceps brachii bone marrow cell oocyte corpus epididymis bronchial epithelial cell thymus mononuclear cell monocyte epithelium of colon Top expressed in uterus white adipose tissue quadriceps femoris muscle muscle of thigh skeletal muscle tissue granulocyte lens pancreas islet of Langerhans neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein heterodimerization activity identical protein binding Cellular component chromosome nucleosome extracellular exosome nucleus nucleoplasm extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8343 319179 Ensembl ENSG00000277224 ENSMUSG00000047246 UniProt P62807 Q6ZWY9 RefSeq (mRNA) NM_003522 NM_001177653 NM_001290530 NM_178194 RefSeq (protein) NP_003517 NP_001368918 NP_001171124 NP_001277459 NP_835501 NP_835503 NP_001277309 NP_075911 Location (UCSC) Chr 6: 26.2 – 26.2 Mb Chr 13: 23.77 – 23.81 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[7]