HIST3H3

Histone H3.1t is a protein that in humans is encoded by the HIST3H3 gene.^[3][4]

H3-4
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2V1D, 2YBP, 2YBS, 3A6N, 3T6R, 4V2W
Identifiers
Aliases	H3-4, H3.4, H3/g, H3FT, H3t, histone cluster 3, H3, histone cluster 3 H3, HIST3H3, H3.4 histone
External IDs	OMIM: 602820; HomoloGene: 133212; GeneCards: H3-4; OMA:H3-4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,424,845 bp[1] End 228,425,360 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis right coronary artery granulocyte ectocervix canal of the cervix mucosa of transverse colon right uterine tube right ovary n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding histone binding protein binding nucleosomal DNA binding Cellular component nucleosome extracellular exosome nucleus chromosome nucleoplasm Biological process negative regulation of protein oligomerization nucleosome assembly protein heterotetramerization double-strand break repair via nonhomologous end joining telomere capping Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8290 n/a Ensembl ENSG00000168148 ENSG00000285435 n/a UniProt Q16695 n/a RefSeq (mRNA) NM_003493 n/a RefSeq (protein) NP_003484 n/a Location (UCSC) Chr 1: 228.42 – 228.43 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.^[5]