HHAT

Hedgehog acyltransferase (HHAT), also called skinny hedgehog homology in humans, is a human gene.^[1][2]

hedgehog acyltransferase
Identifiers
Symbol	HHAT
Alt. symbols	FLJ10724, MART-2, MART2, GUP2
NCBI gene	55733
HGNC	18270
OMIM	605743
RefSeq	NM_018194
UniProt	Q5VTY9
Other data
EC number	2.3.1.-
Locus	Chr. 1 q32
Search for Structures Swiss-model Domains InterPro

The HHAT gene encodes an enzyme that catalyzes N-terminal palmitoylation of sonic hedgehog. Mutations in HHAT produce a phenotype that is similar to loss of hedgehog function. Finally the HHAT protein shares a short but significant sequence similarity to membrane-bound O-acyltransferases.^[3]