HIG1 hypoxia inducible domain family member 1B

HIG1 hypoxia inducible domain family member 1B is a protein that in humans is encoded by the HIGD1B gene. ^[5]

HIGD1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LON
Identifiers
Aliases	HIGD1B, CLST11240, CLST11240-15, HIG1 hypoxia inducible domain family member 1B
External IDs	MGI: 1922939; HomoloGene: 9508; GeneCards: HIGD1B; OMA:HIGD1B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,846,353 bp[1] End 44,850,476 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 102,726,675 bp[2] End 102,728,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right lung upper lobe of left lung left ventricle putamen caudate nucleus anterior cingulate cortex amygdala right frontal lobe nucleus accumbens Top expressed in interventricular septum left lung lobe right lung lobe soleus muscle lumbar subsegment of spinal cord embryo muscle of thigh myocardium of ventricle intercostal muscle embryo More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51751 75689 Ensembl ENSG00000131097 ENSMUSG00000020928 UniProt Q9P298 Q99JY6 RefSeq (mRNA) NM_001271880 NM_016438 NM_080846 NM_001357580 RefSeq (protein) NP_001258809 NP_057522 NP_543122 NP_001344509 Location (UCSC) Chr 17: 44.85 – 44.85 Mb Chr 11: 102.73 – 102.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants.