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HLA-A25

Human leukocyte antigen serotype From Wikipedia, the free encyclopedia

HLA-A25
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HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α25 subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A*25 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2501. A25 and A*25 are almost synonymous in meaning. A25 is a split antigen of the broad antigen serotype A10. A25 is a sister serotype of A26, A34, A43, and A66.

Quick Facts About, Protein ...

A25 is more common in SW Asia to NW Europe. A25 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

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Serotype

A25 reasonably good serotyping with no overt false recognition..

A25 recognition of some HLA A*25 gene products[3]
A*25 A25 A10 Sample
allele%% size (N)
*25019521375

A25 frequencies

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Quick Facts Study population, Saudi Arabia ...

A*2501 distribution is primarily located in Western Eurasia. Frequency tends to be highest in the populations that underwent later neolithization suggesting A*2501 spread in Europe. The high frequency in Saudi Arabia is suggestive of a source.

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References

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