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HLA-B44
Human leukocyte antigen serotype From Wikipedia, the free encyclopedia
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HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.[1]
| ||
| HLA-B (alpha)-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B44 | ||
| Alleles | B*4401, 4402, 4403 . . | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
B44 is a split antigen of the broad antigen B12, and is a sister type of B45.
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Serotype
| B*44 | B44 | B12 | B45 | Sample |
| allele | % | % | % | size (N) |
| *4402 | 98 | 6959 | ||
| *4403 | 94 | 2854 | ||
| *4404 | 65 | 42 | ||
| *4405 | 92 | 130 | ||
| *4406 | 44 | 9 | ||
| B*4401 was shown to be B*4402 after errors corrected. | ||||
| Alleles link-out to IMGT/HLA Database at EBI | ||||
Alleles
![[icon]](#/media/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (July 2010) |
Disease
HLA-B44 increases recurrent sinopulmonary infections.[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).[4] B44 may be a cofactor in ankylosing spondylitis[5]
References
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