HLA-DR10

HLA-DR10 (DR10) is a HLA-DR serotype that recognizes the DRB1*1001 gene product.

major histocompatibility complex, class II, DR10
Haplotypes groups	DQA*01:DRB1*1001
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA[permanent dead link]
EBI-HLA	DRA*0101
Identifiers	beta 1 *1001
Symbol(s)	HLA-DRB1[permanent dead link]
EBI-HLA	DRB1*1001
Shared data
Locus	chr.6 6p21.31

Serology

DR10 serotype recognition of the DRB1*1001 allele gene product^[1]

DRB1*	DR10	DR1		Sample
allele	%	%	%	size (N)
1001	90	4		894

The serological reaction of DR10 is relatively good.

Disease associations

By serotype

DR10 serotype or cognate alleles are associated with: Lichen planus^[2]

By allele

DRB1*1001 is associated with ovarian cancer^[3] and invasive squamous cell cervical cancer (SCC)^[4]

Extended linkage

DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis^[5] The primary involvement appears to be DR10.

Genetic Linkage

DR10 Haplotypes
	DRA	DRB1
Haplotypes	*0101	*1001
	DQA1	DQB1	DRB1
Haplotypes	*0101	*0501	*1001
	HLA-A	HLA-B	DRB1
Haplotypes	*0000	*0000	*1001

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.