HLA-DR15

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

major histocompatibility complex, class II, DR15
Haplotypes groups	DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA[permanent dead link]
EBI-HLA	DRA*0101
Identifiers	beta 1 *1501 to *1505 *1507
Symbol(s)	HLA-DRB1[permanent dead link]
EBI-HLA	DRB1*1501
EBI-HLA	DRB1*1502
EBI-HLA	DRB1*1503
EBI-HLA	DRB1*1504
EBI-HLA	DRB1*1505
EBI-HLA	DRB1*1507
Shared data
Locus	chr.6 6p21.31

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles^[1]

DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively associated Goodpasture syndrome,^[2] early age onset multiple sclerosis,^[3] pernicious anaemia,^[4] sarcoidosis,^[5] hypocretin deficiency associated narcolepsy^[6][7] and a predisposition for postmenopausal osteoporosis.^[8]

DRB1*1501 is positively associated with Goodpasture syndrome,^[9][10] juvenile rheumatoid arthritis,^[11] allergic bronchopulmonary aspergillosis,^[12] multiple sclerosis,^[13] systemic lupus erythematosus,^[14] cervical cancer (human papillomavirus infection),^[15] Sjögren syndrome associated with systemic lupus erythematosus,^[16] and intermediate uveitis.^[17]

DRB1*1502 is associated with systemic lupus erythematosus,^[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.^[19]

DRB1*1503 is associated with Chaga's cardiomyopathy,^[20] allergic bronchopulmonary aspergillosis,^[12] multiple sclerosis,^[13] cervical cancer (human papillomavirus infection).^[21]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)^[21]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus^[18]

Genetic linkage

DR15 Haplotypes
Serotypes	DRA	DRB1	DRB5
DR15(2)-DR51	*0101	*1501	*0101
	*0101	*1502	*0101
	*0101	*1503	*0101
	*0101	*1504	*0101
	*0101	*1505	*0101
	*0101	*1507	*0101
	DQA1	DQB1	DRB1
DR15(2)-DQ6(6.2, 1)	*0102	*0602	*1501
DR15(2)-DQ6(6.1, 1)	*0103	*0601	*1502
	HLA-A	HLA-B	DRB1
A3-Cw7-B7-DR15(2)	*0301	*0702	*1501
A1-B51-DR15(2)	*0101	*5101	*1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.