HLA-DR5

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Illustration of HLA-DR

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles^[1]

DRB1*	DR11	DR5	DR12	Sample
allele	%	%	%	size (N)
11:01	92	5		3474
11:02	89	3		430
11:03	89	4		397
11:04	87	4		2119
11:05	75			4
11:06	20	73		15
11:07	>50			1
11:08	>50			2
11:09	80	20		5
				.
	DR12	DR5	DR11	Sample
12:01	83	4	2	893 [2]
12:02	89			162
12:03	>50			3
12:06	>50			2

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy^[3] and Kaposi's sarcoma in AIDS,^[4] juvenile rheumatoid arthritis,^[5][6] pernicious anemia, Hashimoto's thyroiditis,^[7][8] mycosis fungoides,^[9] polyglandular deficiency syndrome,^[10] systemic sclerosis,^[11][12] childhood epilepsy,^[13] early-onset alopecia areata,^[14] short-ragweed Ra6 allergy,^[15] primary antiphospholipid syndrome,^[16] and increased longevity in the Dutch.^[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).