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HLA-DR8
From Wikipedia, the free encyclopedia
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HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.
| |
human major histocompatibility complex, class II, DR8 | |
| Haplotypes groups | DQA*01:DRB1*0801 to
DQA*01:DRB1*0806 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *0801 to *0806 |
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*0801 |
| EBI-HLA | DRB1*0802 |
| EBI-HLA | DRB1*0803 |
| EBI-HLA | DRB1*0804 |
| EBI-HLA | DRB1*0805 |
| EBI-HLA | DRB1*0806 |
| Shared data | |
| Locus | chr.6 6p21.31 |
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Serology
| DRB1* | DR8 | Sample |
| allele | % | size (N) |
| 0801 | 95 | 1076 |
| 0802 | 96 | 265 |
| 0803 | 88 | 230[2] |
| 0804 | 93 | 186 |
| 0805 | >60 | 5 |
| 0806 | >75 | 13 |
The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.
Disease associations
DR8 is linked to papillary thyroid carcinomas,[3] early onset pauciarticular juvenile chronic arthritis,[4][5] primary biliary cirrhosis[6]
by allele
HLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]
HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]
Genetic Linkage
HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.
References
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