MNX1

Motor neuron and pancreas homeobox 1 (MNX1), also known as Homeobox HB9 (HLXB9), is a human protein encoded by the MNX1 gene.^[5]

MNX1
Identifiers
Aliases	MNX1, HB9, HLXB9, HOXHB9, SCRA1, motor neuron and pancreas homeobox 1
External IDs	OMIM: 142994; MGI: 109160; HomoloGene: 21137; GeneCards: MNX1; OMA:MNX1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 156,994,051 bp[1] End 157,010,663 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 29,678,032 bp[2] End 29,683,468 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas gonad mucosa of transverse colon testicle beta cell mucosa of sigmoid colon duodenum jejunal mucosa rectum mucosa of ileum Top expressed in lumbar subsegment of spinal cord islet of Langerhans female urethra embryo endoderm notochord embryonic organizer tail of embryo pharynx neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleolus nucleus cytosol Biological process regulation of transcription by RNA polymerase II humoral immune response neuron projection morphogenesis spinal cord motor neuron cell fate specification transcription, DNA-templated anatomical structure morphogenesis endocrine pancreas development regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3110 15285 Ensembl ENSG00000130675 ENSMUSG00000001566 UniProt P50219 A2RSX2 RefSeq (mRNA) NM_005515 NM_001165255 NM_019944 RefSeq (protein) NP_001158727 NP_005506 NP_064328 Location (UCSC) Chr 7: 156.99 – 157.01 Mb Chr 5: 29.68 – 29.68 Mb PubMed search [3] [4]
Wikidata
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Clinical significance

Mutations in the MNX1 gene are associated with Currarino syndrome.^[6] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.^[7]