HNRPD

"AUF1" redirects here. For the Austrian media platform, see AUF1 (channel). For other uses, see AUF (disambiguation).

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene.^[5][6] Alternative splicing of this gene results in four transcript variants.

HNRNPD
Available structures PDB Ortholog search: D6RF44 PDBe D6RF44 RCSB List of PDB id codes 1HD0, 1HD1, 1IQT, 1WTB, 1X0F, 2Z5N
Identifiers
Aliases	HNRNPD, AUF1, AUF1A, HNRPD, P37, hnRNPD0, heterogeneous nuclear ribonucleoprotein D
External IDs	OMIM: 601324; MGI: 101947; HomoloGene: 22410; GeneCards: HNRNPD; OMA:HNRNPD - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.22 Start 82,352,498 bp[1] End 82,374,503 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 E4 Start 100,103,794 bp[2] End 100,126,797 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone epithelium of nasopharynx tendon of biceps brachii pylorus endometrium gingival epithelium lactiferous duct germinal epithelium tonsil Top expressed in tail of embryo genital tubercle epiblast ventricular zone mandibular prominence maxillary prominence neural layer of retina abdominal wall ganglionic eminence somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function telomeric DNA binding protein binding minor groove of adenine-thymine-rich DNA binding mRNA binding histone deacetylase binding transcription factor binding chromatin binding mRNA 3'-UTR AU-rich region binding DNA binding nucleic acid binding RNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component cytoplasm cytosol extracellular exosome nucleoplasm nucleus synapse ribonucleoprotein complex Biological process response to electrical stimulus hepatocyte dedifferentiation cellular response to amino acid stimulus positive regulation of transcription, DNA-templated response to estradiol mRNA stabilization response to rapamycin cellular response to putrescine cerebellum development negative regulation of gene expression mRNA splicing, via spliceosome positive regulation of translation RNA processing liver development transcription, DNA-templated regulation of circadian rhythm response to calcium ion response to sodium phosphate 3'-UTR-mediated mRNA destabilization regulation of mRNA stability cellular response to nitric oxide rhythmic process cellular response to estradiol stimulus brain development RNA catabolic process circadian regulation of translation regulation of transcription, DNA-templated positive regulation of gene expression mRNA transcription by RNA polymerase II positive regulation of telomere capping positive regulation of telomerase RNA reverse transcriptase activity regulation of telomere maintenance RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3184 11991 Ensembl ENSG00000138668 ENSMUSG00000000568 UniProt Q14103 Q60668 RefSeq (mRNA) NM_031370 NM_001003810 NM_002138 NM_031369 NM_001077265 NM_001077266 NM_001077267 NM_007516 RefSeq (protein) NP_001003810 NP_002129 NP_112737 NP_112738 NP_001070733 NP_001070734 NP_001070735 NP_031542 Location (UCSC) Chr 4: 82.35 – 82.37 Mb Chr 5: 100.1 – 100.13 Mb PubMed search [3] [4]
Wikidata
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Function

A consensus secondary structure and primary sequence for the targets of the AUF1 RNA binding protein.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). The interaction sites on the RNA are frequently biased towards particular sequence motifs.^[7] These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability.^[6]

Interactions

HnRNP D has been shown to interact with SAFB^[8] and Hsp27.^[9] It also has been reported to interact with mRNAs such as Mef2c mRNA.^[10]