HOCOMOCO

HOCOMOCO^{[1][2] [3][4]} is an open-access database providing curated and benchmarked binding motifs of human and mouse transcription factors. It captures the following data types: Homo sapiens (human) and Mus musculus (mouse) transcription factors, their DNA binding site motifs, and motif subtypes.

HOCOMOCO

Content
Description	Curated collection of binding models for human and mouse transcription factors
Data types captured	Transcription factor binding profiles
Organisms	Homo sapiens, Mus musculus laboratory: autosome.org author: Vorontsov, Makeev, Kulakovskiy
Contact
Primary citation	Vorontsov et al [1]
Access
Website	HOCOMOCO

Introduction

Transcription factors (TFs) are proteins that bind DNA and thus regulate the transcription process. The binding is sequence-specific. A sequence motif^[5] is a model that describes the common pattern of the DNA binding sites^[6] that a particular TF prefers to bind. One of the possible representations of the model is the Position-Weight Matrix (PWM).^[7]

Organisms

• Homo sapiens
• Mus musculus

Recognition

According to the Web of Science, the 2018 publication of HOCOMOCO ^[2] has been cited 396 times (as of January 2024). The publications ^[3][4] have been cited 144 and 151 times.

See also

• Transcription factor binding site databases