BRK1

BRICK1 is a putative micropeptide protein that in humans is encoded by the C3orf10 gene.^[5][6]

BRK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8C, 4N78
Identifiers
Aliases	BRK1, C3orf10, MDS027, hHBrk1, HSPC300, BRICK1, SCAR/WAVE actin nucleating complex subunit, BRICK1 subunit of SCAR/WAVE actin nucleating complex
External IDs	OMIM: 611183; MGI: 1915406; HomoloGene: 10210; GeneCards: BRK1; OMA:BRK1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.3 Start 10,115,675 bp[1] End 10,127,190 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 113,581,733 bp[2] End 113,593,912 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm skin of arm islet of Langerhans right testis monocyte tibial arteries left coronary artery right coronary artery left testis smooth muscle tissue Top expressed in medullary collecting duct external carotid artery endocardial cushion saccule internal carotid artery ureter renal corpuscle olfactory tubercle epithelium of lens otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein-containing complex binding identical protein binding Cellular component cytoplasm cytosol extracellular exosome cytoskeleton SCAR complex lamellipodium Biological process vascular endothelial growth factor receptor signaling pathway Rac protein signal transduction positive regulation of Arp2/3 complex-mediated actin nucleation in utero embryonic development positive regulation of lamellipodium assembly actin cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of cell population proliferation protein homotrimerization actin filament organization cell motility regulation of actin polymerization or depolymerization positive regulation of protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55845 101314 Ensembl ENSG00000254999 ENSMUSG00000033940 UniProt Q8WUW1 Q91VR8 RefSeq (mRNA) NM_018462 NM_133937 RefSeq (protein) NP_060932 NP_598698 Location (UCSC) Chr 3: 10.12 – 10.13 Mb Chr 6: 113.58 – 113.59 Mb PubMed search [3] [4]
Wikidata
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