Histatin 3

Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene.^[3][4]

HTN3
Identifiers
Aliases	HTN3, HIS2, HTN2, HTN5, histatin 3, PB
External IDs	OMIM: 142702; HomoloGene: 133553; GeneCards: HTN3; OMA:HTN3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q13.3 Start 70,028,455 bp[1] End 70,036,538 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad placenta tonsil bone marrow olfactory zone of nasal mucosa anterior pituitary muscle of thigh epithelium of colon skeletal muscle tissue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding Cellular component extracellular region extracellular space Biological process biomineral tissue development defense response to bacterium defense response to fungus antimicrobial humoral response killing of cells of other organism antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3347 n/a Ensembl ENSG00000205649 ENSG00000282967 n/a UniProt P15516 n/a RefSeq (mRNA) NM_000200 n/a RefSeq (protein) NP_000191 n/a Location (UCSC) Chr 4: 70.03 – 70.04 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small, histidine-rich, salivary proteins, encoded by at least two loci (HTN3 and HTN1). Post-translational proteolytic processing results in many histatins: e.g., histatins 4-6 are derived from histatin 3 by proteolysis. Histatins 1 and 3 are primary products of HIS1(1) and HIS2(1) alleles, respectively. Histatins are believed to have important non-immunological, anti-microbial function in the oral cavity.^[3] Histatin 1 and histatin 2 are major wound-closing factors in human saliva.^[5]

allele	gene	protein
HIS1	HTN1	histatin 1
HIS2	HTN3	histatin 3 → histatins 4-6