Haemolysin E

Haemolysin E (HlyE) is a protein family that consists of several enterobacterial haemolysin (HlyE) proteins. Hemolysin E (HlyE) is a novel pore-forming toxin of Escherichia coli, Salmonella typhi, and Shigella flexneri.

Haemolysin E (HlyE)
Structure of E. coli hemolysin E toxin.[1]
Identifiers
Symbol	HlyE
Pfam	PF06109
InterPro	IPR010356
SCOP2	1qoy / SCOPe / SUPFAM
TCDB	1.C.10
OPM superfamily	198
OPM protein	2wcd
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

HlyE is unrelated to the well characterised pore-forming E. coli hemolysins of the RTX family, haemolysin A.

HlyE is a protein of 34 kDa that is expressed during anaerobic growth of E. coli. Anaerobic expression is controlled by the transcription factor, FNR, such that, upon ingestion and entry into the anaerobic mammalian intestine, HlyE is produced and may then contribute to the colonisation of the host.^[1]