Haloprogin

"Polik" redirects here. For other uses, see Polik (disambiguation).

Haloprogin is an antifungal drug used to treat athlete's foot and other fungal infections.^[1] It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik.

Haloprogin

Clinical data
Routes of administration	Topical
ATC code	D01AE11 (WHO)
Legal status
Legal status	US: Not available
Identifiers
IUPAC name 1,2,4-Trichloro-5-[(3-iodoprop-2-yn-1-yl)oxy]benzene
CAS Number	777-11-7 Y
PubChem CID	3561
DrugBank	DB00793 Y
ChemSpider	3440 Y
UNII	AIU7053OWL
KEGG	D00339 Y
ChEMBL	ChEMBL1289 Y
CompTox Dashboard (EPA)	DTXSID9046865
ECHA InfoCard	100.011.169
Chemical and physical data
Formula	C9H4Cl3IO
Molar mass	361.38 g·mol−1
3D model (JSmol)	Interactive image
Melting point	113.5 °C (236.3 °F)
Solubility in water	Insoluble mg/mL (20 °C)
SMILES Clc1cc(OCC#CI)c(Cl)cc1Cl
InChI InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2 Y Key:CTETYYAZBPJBHE-UHFFFAOYSA-N Y
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Action

Haloprogin was previously used in 1% topical creams as an antifungal agent. It was marketed over-the-counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.^[2]

Haloprogin had a high incidence of side effects including: irritation, burning, vesiculation (blisters), scaling, and itching. It has since been discontinued due to the emergence of more modern antifungals with fewer side effects.^[3]