Haplogroup Q-M346

Haplogroup Q-M346 is a subclade of Y-DNA Haplogroup Q. Haplogroup Q-M346 is defined by the presence of the M346 Single Nucleotide Polymorphism (SNP).

Haplogroup Q-M346
Possible time of origin	24,100-27,900 BP
Possible place of origin	Eurasia
Ancestor	Q-MEH2[1]
Descendants	Q-L54, Q-M323[1]
Defining mutations	L56, L57, M346 [1]

Origin and distribution

Q-M346 was discovered in Central Asia and announced in Sengupta 2006.^[2] A latter paper suggested that its ancestral state was isolated to India,^[3] but this has since been refuted by its presence in West Asia,^[4] Europe^{[citation needed]} and the Americas.^[5]

Asia

Q-M346 has a wide distribution across much of Asia.^[6][7][8][9]

Population		Paper	N	Percentage	SNP Tested
Altaians (Russia - Siberia)		Malyarchuk 2011 [6]	23/89	~25.8%	M346
Khakassians (Russia - Siberia)		Malyarchuk 2011 [6]	4/64	~6.3%	M346
Todjins (Russia - Siberia)		Malyarchuk 2011 [6]	10/26	~38.5%	M346
Tuvinians (Russia - Siberia)		Malyarchuk 2011 [6]	41/108	~38.0%	M346
Soyot/Sojots (Russia - Siberia)		Malyarchuk 2011 [6]	2/28	~7.1%	M346
Kalmyks		Malyarchuk 2011 [6]	1/60	~1.7%	M346
Halba		Sengupta 2006 [2]	1/21	~4.76%	M346
Makrani		Sengupta 2006 [2]	1/20	~5.00%	M346
Pathan		Sengupta 2006 [2]	2/21	~5.00%	M346
Brahmin (Uttar Pradesh, India)		Sengupta 2006 [2]	1/14	~7.14%	M346
Vellalar (South India)		Sengupta 2006 [2]	1/31	~3.23%	M346
Pakistan		Abu-Amero 2009 [7]	3/176	~1.70%	M346
Kazakhs (Southwest Altai)		Dulik 2011 [8]	1/30	~3.33%	M346
Chelkan (Russia - Siberia)		Dulik 2012 [9]	15/25	~60.00%	M346
Tubalar Russia - Siberia]		Dulik 2012 [9]	10/27	~37.00%	M346

The Americas

In the Americas, the founding paternal lineages include those who are Q-M346 but do not belong to the Q-M3 lineage.^[5][10]

Population		Paper	N	Percentage	SNP Tested
Enxet		Bailliet 2009 [5]	7/24	~29.20%	M346
Ayoreo		Bailliet 2009 [5]	2/9	~22.20%	M346
Wichi		Bailliet 2009 [5]	1/120	~0.80%	M346
Mocovi		Bailliet 2009 [5]	2/40	~5.00%	M346
Mapuche		Bailliet 2009 [5]	1/26	~3.80%	M346
Salta		Bailliet 2009 [5]	3/72	~4.80%	M346
Cordoba		Bailliet 2009 [5]	1/156	~0.60%	M346
Huilliche		Bailliet 2009 [5]	1/26	~3.80%	M346
La Paz		Bailliet 2009 [5]	1/29	~3.40%	M346
Tarija		Bailliet 2009 [5]	4/72	~5.50%	M346

Associated SNPs

Q-M346 is marked by the presence of the M346 SNP. Since the discovery of M346 several additional SNPs have been found to also be associated with Q-M346. These SNP's include: L56 and L57. These SNPs appear to be "parallel" to M346.^[1]

Subgroups

This is Thomas Krahn's—of the Genomic Research Center—draft tree, Proposed Tree, for haplogroup Q-M346. The first three levels of subclades are shown. Additional detail is provided on the linked branch article pages.^[1]

• Q-MEH2 MEH2, L472, L528
  • Q-M346 M346, L56, L57, L474, L892, L942
    • Q-M323 M323
    • Q-L717 L717, L718
    • Q-L940 L940
      • Q-L527 L527, L529, L639
      • Q-L933 L933, L938, L941
    • Q-L53 L53, L55, L213, L331, L475, L476
      • Q-L54 L54

See also

• Human Y-chromosome DNA haplogroup

Y-DNA Q-M242 subclades

• Q-M242
• Q-L275
• Q-L330
• Q-L717
• Q-L940
• Q-L53
• Q-L54
• Q-M120
• Q-B143
• Q-M25
• Q-M3
• Q-M323
• Q-M346
• Q-NWT01
• Q-P89.1
• Q-Z780

Y-DNA backbone tree