Heme ligase

Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe³⁺:ferriprotoporphyrin IX ligase (β-hematin-forming).^[1] This enzyme catalyses the following reaction:

2 ferriprotoporphyrin IX ${\displaystyle \rightleftharpoons }$ beta-hematin

Heme ligase
Identifiers
EC no.	4.99.1.8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
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This heme detoxifying enzyme is found in Plasmodium parasites.