HMOX2

Heme oxygenase 2 is an enzyme that in humans is encoded by the HMOX2 gene.^[5][6]

HMOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q32, 2QPP, 2RGZ, 4WMH
Identifiers
Aliases	HMOX2, HO-2, heme oxygenase 2
External IDs	OMIM: 141251; MGI: 109373; HomoloGene: 1611; GeneCards: HMOX2; OMA:HMOX2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 4,474,690 bp[1] End 4,510,347 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.46 cM Start 4,544,225 bp[2] End 4,584,606 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis prefrontal cortex left ventricle apex of heart superior frontal gyrus Brodmann area 9 right auricle of heart nucleus accumbens body of stomach Top expressed in spermatid seminiferous tubule facial motor nucleus anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell supraoptic nucleus stroma of bone marrow endothelial cell of lymphatic vessel external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity protein binding metal ion binding heme oxygenase (decyclizing) activity heme binding Cellular component intracellular membrane-bounded organelle endoplasmic reticulum membrane membrane endoplasmic reticulum plasma membrane specific granule membrane Biological process response to hypoxia cellular iron ion homeostasis heme oxidation response to oxidative stress heme catabolic process neutrophil degranulation iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3163 15369 Ensembl ENSG00000277424 ENSG00000103415 ENSMUSG00000004070 UniProt P30519 O70252 RefSeq (mRNA) NM_001127204 NM_001127205 NM_001127206 NM_001286267 NM_001286268 NM_001286269 NM_001286270 NM_001286271 NM_002134 NM_001136066 NM_010443 NM_001357050 NM_001378999 RefSeq (protein) NP_001120676 NP_001120677 NP_001120678 NP_001273196 NP_001273197 NP_001273198 NP_001273199 NP_001273200 NP_002125 NP_001129538 NP_034573 NP_001343979 NP_001365928 Location (UCSC) Chr 16: 4.47 – 4.51 Mb Chr 16: 4.54 – 4.58 Mb PubMed search [3] [4]
Wikidata
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Function

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.^[6]