Hexahydrocannabihexol

Hexahydrocannabihexol (HHCH) is a semi-synthetic cannabinoid derivative. It was first synthesised by Roger Adams in 1942 and found to be more potent than either the pentyl or heptyl homologues, or the unsaturated tetrahydrocannabinol analogue.^[1][2] HHCH was first identified as a designer drug in Sweden in September 2023.^[3]

Hexahydrocannabihexol

Identifiers
IUPAC name (6aR,10aR)-6,6,9-trimethyl-3-hexyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Chemical and physical data
Formula	C22H34O2
Molar mass	330.512 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCCc1cc2OC(C)(C)[C@@H]3CCC(C)C[C@H]3c2c(O)c1
InChI InChI=InChI=1S/C22H34O2/c1-5-6-7-8-9-16-13-19(23)21-17-12-15(2)10-11-18(17)22(3,4)24-20(21)14-16/h13-15,17-18,23H,5-12H2,1-4H3/t15?,17-,18-/m1/s1 Key:OKXUDFJPZMVBEH-HSFDIDPMSA-N

Legality

HHCH is classified as an "intoxicating cannabinoid" in Colorado and requires a license for its manufacture or distribution.^[4]

In Japan, after several people who had eaten gummy candies containing HHCH fell ill, this chemical was officially added to the list of designated substances. And since 2 December 2023, it has been illegal to possess, use, or sell it.^[5]

See also

• Hexahydrocannabinol (HHC)
• Hexahydrocannabiphorol (HHCP)
• Parahexyl
• Tetrahydrocannabihexol (THCH)