Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) (EC 2.5.1.83, HexPS, hexaprenyl pyrophosphate synthetase, hexaprenyl diphosphate synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units).^[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate ${\displaystyle \rightleftharpoons }$ 3 diphosphate + all-trans-hexaprenyl diphosphate

Hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Identifiers
EC no.	2.5.1.83
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate.