Rs6314

In genetics, rs6314, also called His452Tyr or H452Y, is a gene variation, a single nucleotide polymorphism (SNP), in the HTR2A gene that codes for the 5-HT_2A receptor. The SNP is located in exon 3 of the gene and the change between C and T results in a change between histidine (His) and tyrosine (Tyr) at the 452nd amino acid, i.e., it is a missense substitution.^[1]

SNP: rs6314
Name(s)	His452Tyr, H452Y
Gene	HTR2A
Chromosome	13
Region	Exon 3
External databases
Ensembl	Human SNPView
dbSNP	6314
HapMap	6314
SNPedia	6314
SzGene	Meta-analysis Overview

As 5-HT_2A is a neuroreceptor the SNP has been investigated in connection with neuropsychiatric disorders^[2] and other brain-related variables. A 2003 study looked at memory performance and found that His/His subjects performed better.^[3] Another study reported that the SNP had an effect on the memory performance in young adults.^[4] This has been replicated by another group.^[5]

The His452Tyr variant may influence cell signaling.^[6]

rs6311, rs6313 and rs7997012 are other investigated SNPs in the HTR2A gene.