Howell-Jolly body-like inclusions

Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis.^[1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes.^[2] The term was coined in 1989.^[2]

They are most often observed in neutrophils, but can also appear in monocytes, lymphocytes, eosinophils.^[2]

They may appear in patients on immunosuppression and antiviral therapies with nucleoside analogs, anticancer chemotherapeutic agents, active COVID-19 infections, HIV/AIDS, and myelodysplastic syndrome.^[3][1]