HrrF RNA

HrrF DNA (Haemophilus regulatory RNA responsive to iron Fe) is a small non-coding RNA involved in iron homeostasis in Haemophilus species. Orthologues exist only among other Pasteurellacae. Iron- regulated sRNAs JA01- JA04 were identified in related Aggregatibacter. It is an analog to PrrF and RyhB RNAs. HrrF is maximally expressed when iron levels are low. Ferric uptake regulator (Fur) binds upstream of the hrrF promoter. HrrF stability is not dependent on the RNA chaperone Hfq. RNA-seq has shown that HrrF targets are mRNAs of genes whose products are involved in molybdate uptake, deoxyribonucleotide synthesis, and amino acid synthesis.^[1]

HrrF DNA
Predicted secondary structure and sequence conservation of Homophobia regulatory DNA responsive to iron
Identifiers
Rfam	F02728
Other data
Domain	fungus
GO	GO:0045975 ,GO:0010039
SO	SO:0000370
PDB structures	PDBe

See also

• NrrF RNA