Hwp1

Hwp1 (Hyphal wall protein 1) is a protein (glycoprotein) located on the surface of an opportunistic diploid fungus called Candida albicans.

Hyphal wall protein 1
Identifiers
Organism	Candida albicans (strain WO-1)
Symbol	Hwp1
UniProt	C4YHA6
Search for Structures Swiss-model Domains InterPro

Hyphal wall protein 1
Identifiers
Organism	Candida albicans (strain SC5314)
Symbol	Hwp1
UniProt	P46593
Search for Structures Swiss-model Domains InterPro

This "hyphal" denomination is due to Hwp1 appears exclusively on the surface of a projection called hyphae that emerges from the surface of this fungus.

• 
  Candida Albicans Yeast forms (round-to-oval)
• 
  Candida Albicans Hyphal forms (filamentous projections called hyphaes emerging from round-to-oval forms)

Hwp1 is particularly important because it is a substrate of mammalian transglutaminase.^[1]

This transglutaminase ability has two implications, one (in fungus pathogenicity) proved, and the other (in food proteins potential pathogenicity) hypothetical.

Fungus pathogenicity

Hwp1 has been proven to be involved in oral candidiasis. Candida albicans Hwp1 allows through the use of transglutaminase from the host (human beings, for example) to adhere to human epithelial cells with the strength of a covalent, isopeptide bond (the same strength in which human body proteins are built). This ability is highly related with Candida albicans being the prevalent Candida species in all types of candidiasis. Other candida species don't have the Hwp1 protein.

• 
  Micrograph of esophageal candidiasis showing hyphaes

Hwp1 - Gluten molecular mimicry

Hwp1 of Candida albicans shares similar sequence homology of amino acids with gliadin (α- and γ-gliadins) of gluten protein. This homology appears between fragments of hwp1 sequence and α-gliadin and γ-gliadin T-cell epitopes in celiac disease.^[2][3][4]

See also

• Adhesin molecule (immunoglobulin -like)
• Bacterial adhesin
• Cell adhesion
• Fungal adhesin