Hydrogenase (NAD+, ferredoxin)

Hydrogenase (NAD+, ferredoxin) (EC 1.12.1.4, bifurcating [FeFe] hydrogenase) is an enzyme with systematic name hydrogen:NAD⁺, ferredoxin oxidoreductase.^[1][2] This enzyme catalyses the following chemical reaction

2 H₂ + NAD⁺ + 2 oxidized ferredoxin ${\displaystyle \rightleftharpoons }$ 5 H⁺ + NADH + 2 reduced ferredoxin

Hydrogenase (NAD+, ferredoxin)
Identifiers
EC no.	1.12.1.4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme from Thermotoga maritima contains a [Fe-Fe] cluster (H-cluster) and iron-sulfur clusters. I