Hydroxycyclohexanecarboxylate dehydrogenase

In enzymology, hydroxycyclohexanecarboxylate dehydrogenase (EC 1.1.1.166) is an enzyme that catalyzes the chemical reaction

3,4-dihydroxycyclohexane-1-carboxylic acid

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

4-hydroxy-3-oxocyclohexane-1-carboxylic acid

+ NADH

 

hydroxycyclohexanecarboxylate dehydrogenase
Identifiers
EC no.	1.1.1.166
CAS no.	55467-53-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The two substrates of this enzyme are (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylic acid, reduced NADH, and a proton.^[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD⁺ 3-oxidoreductase. Other names in common use include dihydroxycyclohexanecarboxylate dehydrogenase, and (−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD⁺ oxidoreductase.